Preoptic activation and connectivity during thermal sweating in humans

Abstract

Animal studies have identified the preoptic area as the key thermoregulatory region of the brain but no comparable information exists in humans. We used fMRI to study the preoptic area of human volunteers. Subjects lay in a 3T MRI scanner and were subjected to whole body heating by a water-perfused suit, to a level that resulted in a low rate of discrete sweating events (measured by finger skin resistance). Control scans were taken under thermoneutral conditions in another group. A discrete cluster of voxels in the preoptic area showed activity that was significantly correlated with thermal sweating events. We then used this cluster as a seed to investigate whether other brain areas had acti..